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<th style="background:#f5f9ff;color:#1890ff;padding:15px 12px;text-align:left;font-weight:600;border-bottom:2px solid #1890ff;border-right:1px solid #e8e8e8;">基因</th>
<th style="background:#f5f9ff;color:#1890ff;padding:15px 12px;text-align:left;font-weight:600;border-bottom:2px solid #1890ff;border-right:1px solid #e8e8e8;">临床意义</th>
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<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">CYP2C9</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">磺脲类降糖药（如格列本脲、格列美脲）、华剂量。</td>
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<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">CYP2C19</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">氯吡格雷、质子泵抑制剂（如奥美拉唑）、某些抗抑郁药</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">CYP2D6</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">美托洛尔、曲马多、;">SLCO1B1</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">他汀类药物（如辛伐他汀、阿托伐他汀）</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">正常活性型、低活性型</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">低活性型: 1px solid #ddd;">DPYD</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">氟尿嘧啶类化疗药（如5-FU、卡培他: 8px; border: 1px solid #ddd;">UGT1A1</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">伊立替康、某些非甾体抗炎药</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">正常活性型、低活性型</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">HLA-B*58:01</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">别嘌醇</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">阳性、阴性</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">HLA-B*5px; border: 1px solid #ddd;">KIF6</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">二甲双胍</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">不同基因型</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;line-height:1.6;">与二甲双胍的疗效及乳在临床各科室的广泛应用正逐步改变传统的“一刀切”治疗模式，推动精准医疗的实现。通过识别个体基因差异，医生能够更科学地选择药物、调整剂量，从而提升治疗效果并
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