在菏泽市曹县做DNA损伤修复45+肿瘤同源重组缺陷（HRD）基因检测，推荐曹县万核医学基因检测咨询中心提供专业的DNA损伤修复45+肿瘤同源重组缺陷（HRD）基因检测检测服务。预约电话：400-178-9498
DNA损伤修复45。</p>
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<th style="background:linear-gradient(135deg,#667eea 0%,#764ba2 100%);color:#fff;padding:15px 12px;text-align:left;font-weight:600;border:none;">基因/生物标志物</th>
<th style="background:linear-gradient(135deg,#667eea 0%,#764ba2 100%);color:#fff;padding:15px 12px;text-align:left;font-weight:600;border:none;">靶向药（部分）</th>
<th style="background:linear-gradient(135deg,#667eea 0%,#764ba2 100%);color:#fff;padding:15px 12px;text-align:left;font-weight:600;border:none;">主要适应症</th>
<th style="background:linear-gradient(135deg,#667eea 0%,#764ba2 100%);color:#fff;padding:15px 12px;text-align:left;font-weight:600;border:none;">临床意义</th>
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<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;">奥拉帕利、尼拉帕利、卢卡帕利、他拉唑突变也可能导致HRD，提示对PARP抑制剂可能敏感，为治疗提供潜在依据。</td>
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<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;">HRD评分（LOH/TAI/LST）</td>
<td style="padding:12px;border-bottom:1px solid #e8e8e8;border-right:1px solid #e8e8e8;">，NGS能够结合测序数据计算LOH、TAI、LST等基因组不稳定指数，综合判定HRD状态。</li>
<li><strong>优势：</strong> 检测范围广（可同时检测45+基因及HRD状态）、灵敏度高（可检测低丰度突变）、准确性高、信息量大、能够区分生殖系和体细胞突变，并对肿瘤异质性有更好的捕获能力。是目前基因组学研究和临床检测的主流技术。</li>
<li><strong>本产品应用：</strong> 采用NGS技术，通过对组织（肿瘤）和血液（白细胞）样本的DNA进行深度测序，
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